Blar i Brage NIH på forfatter "Godwin, Joshua S."

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    • Different resistance exercise loading paradigms similarly affect skeletal muscle gene expression patterns of myostatin-related targets and mTORC1 signaling markers 

      McIntosh, Mason C; Godwin, Joshua S.; Michel, J. Max; Plotkin, Daniel L.; Ziegenfuss, Tim N.; Lopez, Hector L.; Smith, Ryan; Dalbo, Vincent J.; Sexton, Casey L.; Ruple, Bradley A.; Dwaraka, Varun B.; Sharples, Adam P.; Mobley, Christopher Brooks; Vann, Christopher G.; Roberts, Michael D. (Peer reviewed; Journal article, 2023)
      Although transcriptome profiling has been used in several resistance training studies, the associated analytical approaches seldom provide in-depth information on individual genes linked to skeletal muscle hypertrophy. ...

    • Resistance training rejuvenates the mitochondrial methylome in aged human skeletal muscle 

      Ruple, Bradley A; Godwin, Joshua S.; Mesquita, Paulo H. C; Osburn, Shelby C; Vann, Christopher G; Lamb, Donald A; Sexton, Casey L; Candow, Darren G; Forbes, Scott C; Frugé, Andrew D.; Kavazis, Andreas N; Young, Kaelin C; Seaborne, Robert A.; Sharples, Adam; Roberts, Michael D (Peer reviewed; Journal article, 2021)
      Resistance training (RT) dynamically alters the skeletal muscle nuclear DNA methylome. However, no study has examined if RT affects the mitochondrial DNA (mtDNA) methylome. Herein, ten older, Caucasian untrained males (65 ...

    • Skeletal muscle DNA methylation and mRNA responses to a bout of higher versus lower load resistance exercise in previously trained men 

      Sexton, Casey L.; McIntosh, Mason C.; Ruple, Bradley A.; Osburn, Shelby C.; Hollingsworth, Blake R.; Kontos, Nicholas J.; Agostinelli, Philip J.; Kavazis, Andreas N.; Ziegenfuss, Tim N.; Lopez, Hector L.; Young, Kaelin C.; Dwaraka, Varun B.; Mobley, Christopher B.; Sharples, Adam P.; Godwin, Joshua S.; Smith, Ryan; Frugé, Andrew D.; Roberts, Michael D. (Peer reviewed; Journal article, 2023)
      We sought to determine the skeletal muscle genome-wide DNA methylation and mRNA responses to one bout of lower load (LL) versus higher load (HL) resistance exercise. Trained college-aged males (n = 11, 23 ± 4 years old, 4 ...